1. The major route of metabolism is by its target enzymes via cholinesterase-mediated hydrolysis. 2. The ANSM committee also requested data on non-target enzyme affinity from the manufacturer Bial. 3. The target enzyme in HIV cannot distinguish the difference, but human enzymes can, he said. 4. The kinase then phosphorylates target enzymes , regulating their activities. 5. More research is needed to identify inhibitors that selectively target enzymes in the glyoxylate cycle. 6. Some reversible inhibitors bind so tightly to their target enzyme that they are essentially irreversible. 7. Mevastatin was demonstrated to be an unusually potent inhibitor of the target enzyme and of cholesterol biosynthesis. 8. The "'mannose 6-phosphate receptors ( MPRs ) "'are transmembrane glycoproteins that target enzymes to lysosomes in vertebrates. 9. In drug design it is important to consider the concentrations of substrates to which the target enzymes are exposed. 10. A homotropic allosteric modulator is a substrate for its target enzyme , as well as a regulatory molecule of the enzyme's activity.
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